Description

Fmoc-D-Dab(Dde)-Oh is a protected amino acid derivative essential for advanced solid-phase peptide synthesis (SPPS). This compound, with CAS No. 596797-14-7, is specifically engineered to provide orthogonal protection for the side chain amine of diaminobutyric acid (Dab), enabling the sequential and controlled assembly of complex peptides. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and novel biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the sequential incorporation of Dab with orthogonal side-chain protection.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR) around cationic amino acid residues.
• Material Science: Can be used in the synthesis of peptide-based biomaterials and surfaces where controlled presentation of functional groups is required.

Basic Information

Product Name	Fmoc-D-Dab(Dde)-Oh
CAS No.	596797-14-7
Molecular Formula	C30H35N3O6
Molecular Weight	533.62 g/mol
Synonyms	Fmoc-D-2,4-diaminobutyric acid(Dde)-OH; N-α-Fmoc-N-δ-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)-D-2,4-diaminobutanoic acid; Fmoc-D-Dab(Dde)-OH; Fmoc-D-Dab(Dde); (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]butanoic acid; D-Dab(Dde)-Fmoc
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dab(Dde)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals used in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.