Description

Butanoic Acid, 4-Chloro-3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Oxo-, Methyl Ester, (3S)- is a sophisticated chiral building block and protected amino acid derivative, essential for advanced organic synthesis. This high-purity intermediate is critical for researchers and manufacturers requiring precise stereochemistry and functional group manipulation in complex molecule construction. It is primarily utilized in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where the integrity of the (3S)-stereocenter and the Fmoc-protected amine are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Serves as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains.
• Chemical Biology & Proteomics: Used in the synthesis of activity-based probes, labeled peptides, and other tools for studying protein function and interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Agrochemical Research: Potential application in the synthesis of chiral active ingredients for crop protection products.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	Butanoic Acid, 4-Chloro-3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-4-Oxo-, Methyl Ester, (3S)-
CAS No.	596095-91-9
Molecular Formula	C21H20ClNO6
Molecular Weight	417.84 g/mol
Synonyms	(3S)-4-Chloro-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-oxobutanoic acid methyl ester; Fmoc-Asp(OtBu)-Cl; Fmoc-L-Aspartic acid 4-tert-butyl ester β-benzyl ester; Methyl (3S)-4-chloro-3-[(9H-fluoren-9-ylmethoxy)formamido]-4-oxobutanoate; Fmoc-Asp(OtBu)-OBzl; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-tert-butyl ester β-benzyl ester; A protected aspartic acid derivative; Chiral Fmoc-amino acid chloride.
EINECS	Contact for details

Quality Control

Our production of this advanced chemical intermediate adheres to stringent quality protocols to ensure high chiral purity and batch-to-batch consistency, which are critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.