Description

Fmoc-Aza-L-Leucine CAS NO 587880-86-2 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique structural and functional properties of the aza-amino acid moiety into peptide chains, enabling the development of novel bioactive molecules. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies focused on creating next-generation peptide therapeutics, protease inhibitors, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, used to incorporate aza-leucine residues into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Serves as a crucial intermediate in the research and development of novel peptide-based drugs, enzyme inhibitors, and targeted therapeutics.
• Protease Inhibitor Design: Used to synthesize peptide analogs that mimic transition states, specifically for creating inhibitors of aspartyl proteases and other enzyme families.
• Chemical Biology & Bioconjugation: Enables the site-specific introduction of modified amino acids into proteins and peptides for studying structure-activity relationships (SAR) and protein function.
• Peptidomimetics Development: Facilitates the creation of peptidomimetic compounds with enhanced metabolic stability, bioavailability, and receptor binding affinity compared to natural peptides.
• Academic & Institutional Research: A vital reagent for universities and research institutes conducting fundamental studies in organic synthesis, peptide chemistry, and pharmaceutical sciences.

Basic Information

Product Name	Fmoc-Aza-L-Leucine
CAS No.	587880-86-2
Molecular Formula	C₂₂H₂₄N₂O₅
Molecular Weight	396.44 g/mol
Synonyms	Fmoc-L-Azaleucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-azaleucine; (2S)-5-Methyl-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]pentanoic acid; Fmoc-AzLeu-OH; Fmoc-aza-Leu-OH; Nα-Fmoc-L-azaleucine; Fmoc-L-2-Aza-4-methylpentanoic acid; N-Fmoc-L-azaleucine
EINECS	Contact for details

Quality Control

Our Fmoc-Aza-L-Leucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.