Description

Rac 3-o-Methyl Dopa-D3 is a deuterium-labeled isotopologue of the catechol-O-methyltransferase (COMT) metabolite of L-DOPA. This compound is a critical reference standard and analytical tool for pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in neuroscience and drug metabolism research. The deuterium labeling provides a stable, non-radioactive tracer for precise quantification via mass spectrometry.

Application

• Pharmacokinetic Studies: Used as an internal standard for the accurate quantification of 3-O-Methyldopa in biological matrices (plasma, urine, CSF) via LC-MS/MS.
• Drug Metabolism Research: Essential for tracing the metabolic pathways of L-DOPA and investigating COMT enzyme activity in vitro and in vivo.
• Biomarker Analysis: Facilitates the development and validation of high-sensitivity assays for monitoring Parkinson's disease therapy and related neurological conditions.
• Reference Material: Serves as a certified reference standard for quality control in the manufacturing of active pharmaceutical ingredients (APIs) and finished drug products.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly accurate and precise measurements due to its nearly identical chemical properties to the analyte, minimizing matrix effects.

Basic Information

Product Name	Rac 3-o-Methyl Dopa-D3
CAS No.	586954-09-8
Molecular Formula	C10H10D3NO4
Molecular Weight	215.23 g/mol
Synonyms	(±)-3-O-Methyl-Dopa-d3; DL-3-O-Methyldopa-d3; 3-Methoxy-DL-dopa-d3; 2-Amino-3-(3-methoxy-4-hydroxyphenyl)propanoic-2,5,6-d3 acid; 3-OMD-d3; Racemic 3-O-Methyl Dopa Deuterated; 3-Methoxytyrosine-d3; L-DOPA Metabolite-d3
EINECS	Contact for details

Quality Control

Every batch of Rac 3-o-Methyl Dopa-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), isotopic enrichment (≥98 atom % D), and absence of critical impurities. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.