Description

Benzamide, 4-Cyano-2-Fluoro-n-(4-Methylphenyl)- (9Ci) CAS NO 586368-41-4 is a specialized fluorinated and cyanated benzamide derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its molecular architecture, featuring both electron-withdrawing cyano and fluoro substituents, makes it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, leveraging its unique substitution pattern for bioactivity.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the reactive fluoro and cyano groups.
• Academic & Institutional R&D: Employed in universities and research institutes for methodological studies and exploring new chemical spaces in medicinal and synthetic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise molecular scaffold.

Basic Information

Product Name	Benzamide, 4-Cyano-2-Fluoro-n-(4-Methylphenyl)- (9Ci)
CAS No.	586368-41-4
Molecular Formula	C15H11FN2O
Molecular Weight	254.26 g/mol
Synonyms	4-Cyano-2-fluoro-N-(4-methylphenyl)benzamide; 2-Fluoro-4-cyano-N-(p-tolyl)benzamide; N-(4-Methylphenyl)-2-fluoro-4-cyanobenzamide; Benzamide, N-(4-methylphenyl)-2-fluoro-4-cyano-; 586368-41-4; 4-Cyano-2-fluoro-N-(4-methylphenyl)benzamide (9CI)
EINECS	Contact for details

Quality Control

Every batch of Benzamide, 4-Cyano-2-Fluoro-n-(4-Methylphenyl)- (9Ci) is produced and analyzed under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.