Description

Boc-D-Phe(4-Nhboc)-Oh is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound is a critical building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, offering orthogonal protection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including peptide-based drugs and bioactive probes. Its high purity and defined stereochemistry are essential for ensuring the fidelity and success of sophisticated synthetic sequences.

Application

• Peptide Synthesis: A key intermediate in the synthesis of custom peptides, particularly those requiring the incorporation of protected D-phenylalanine derivatives.
• Pharmaceutical Research: Used in the research and development of peptide-based pharmaceuticals, hormone analogs, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide conjugates for diagnostic and biochemical studies.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships and synthetic methodology development.

Basic Information

Product Name	Boc-D-Phe(4-Nhboc)-Oh
CAS No.	583870-09-1
Molecular Formula	C₂₅H₃₂N₂O₆
Molecular Weight	456.53 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-ω-(tert-butoxycarbonyl)-D-4-aminophenylalanine; Boc-D-4-(Boc-amino)phenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid; Boc-D-Phe(4-NH-Boc)-OH; D-Boc-Phe(4-NHBoc)-OH; Boc-D-4-Aminophenylalanine(Boc)-OH; tert-Butyl (R)-(1-((tert-butoxycarbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)-1-oxopropan-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-D-Phe(4-Nhboc)-Oh is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰/D: Specific range available on COA
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.