Description

(Cys46)-Hiv-1 Tat Protein (46-57) Amide Trifluoroacetate Salt H-Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Nh2 Trifluoroacetate Salt is a synthetic peptide fragment derived from the HIV-1 Tat protein, specifically the arginine-rich basic domain, and is supplied as a high-purity trifluoroacetate salt. This compound is a critical research tool for studying viral transcription, cell penetration mechanisms, and the development of novel therapeutic and diagnostic strategies. It is primarily utilized by biotechnology and pharmaceutical R&D teams, as well as academic researchers focused on virology, neurobiology, and drug delivery systems.

Application

• Biomedical Research: Fundamental studies on HIV-1 Tat protein function, structure-activity relationships, and its role in viral replication and transactivation.
• Cell Penetration Studies: Investigation of cell-penetrating peptide (CPP) mechanisms due to the Tat peptide's ability to efficiently cross cell membranes.
• Therapeutic Development: As a reference standard or active component in the research of anti-HIV therapeutics, gene therapy vectors, and targeted drug delivery platforms.
• Diagnostic Reagent Development: Used in the development and validation of immunoassays, ELISA kits, and other diagnostic tools for detecting HIV-related biomarkers.
• Neuroscience Research: Study of Tat protein's neurotoxic effects and its implications in HIV-associated neurocognitive disorders (HAND).
• Bioconjugation & Probe Synthesis: The cysteine residue at position 46 allows for site-specific conjugation with fluorophores, biotin, or other tags for imaging and pull-down assays.

Basic Information

Product Name	(Cys46)-Hiv-1 Tat Protein (46-57) Amide Trifluoroacetate Salt H-Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Nh2 Trifluoroacetate Salt
CAS No.	583836-55-9
Molecular Formula	C78H147N45O18S • xC2HF3O2
Molecular Weight	~1992.2 g/mol (Free base)
Synonyms	Tat (46-57) amide; HIV-1 Tat Protein Fragment (46-57); H-Cys-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2 TFA salt; Tat Basic Domain Peptide; Cys-Tat(46-57); Cell-Penetrating Tat Peptide; Arg-rich Tat peptide; GRKKRRQRRRPPQ peptide (Cys46 variant); TFA salt of HIV Tat (46-57) amide
EINECS	Contact for details

Quality Control

Our (Cys46)-Hiv-1 Tat Protein (46-57) Amide Trifluoroacetate Salt is manufactured under strict quality systems suitable for research applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results for purity (HPLC), molecular weight confirmation (MS), and other critical parameters. We support research requiring traceability and reliable quality.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak consistent with theoretical mass
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
TFA Content	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.