Description

Bax Inhibiting Peptide V5 (Bip-V5) CAS NO 579492-81-2 is a potent, cell-permeable pentapeptide designed to specifically inhibit the pro-apoptotic protein Bax, a key regulator of mitochondrial apoptosis. This compound matters significantly for researchers and developers seeking to modulate programmed cell death pathways, offering a critical tool for studying apoptosis and exploring therapeutic interventions. It is primarily needed by pharmaceutical R&D teams, academic researchers in cell biology and oncology, and biotechnology companies focused on developing treatments for cancer, neurodegenerative diseases, and other conditions involving dysregulated apoptosis.

Application

• Apoptosis Research: A fundamental tool for investigating the intrinsic (mitochondrial) pathway of programmed cell death in vitro.
• Oncology Studies: Used to inhibit Bax-induced apoptosis in cancer cell lines to study chemoresistance mechanisms and identify potential drug targets.
• Neuroprotection Research: Applied in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, stroke) to assess the role of Bax in neuronal cell death.
• Cardioprotection Studies: Utilized in ischemia-reperfusion injury models to examine the contribution of mitochondrial apoptosis in heart tissue.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput screens for novel apoptosis modulators.
• Mechanistic Biochemistry: Employed to elucidate protein-protein interactions within the Bcl-2 family and their functional consequences.

Basic Information

Product Name	Bax Inhibiting Peptide V5 (Bip-V5)
CAS No.	579492-81-2
Molecular Formula	C30H49N9O7
Molecular Weight	647.8 g/mol
Synonyms	BIP-V5; Bax Inhibitor Peptide V5; Phenylacetyl-Val-Asp-Met-Leu-Lys; Bax-Inhibiting Peptide; BIP; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-4-methylsulfanylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-carbamoylbutanoyl]amino]-N-[(2S,3S)-1-[[(2S)-2,6-diaminohexanoyl]amino]-3-methyl-1-oxopentan-2-yl]pentanediamide
EINECS	Contact for details

Quality Control

Our Bax Inhibiting Peptide V5 (Bip-V5) is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each batch to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.