Description

2-(2'-Di-tert-Butylphosphine)Biphenyl is a specialized, air-sensitive organophosphorus ligand widely used in homogeneous catalysis. This compound matters for its exceptional electron-donating properties and steric bulk, which are critical for enhancing catalyst activity and selectivity in demanding cross-coupling reactions. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing and scaling up efficient synthetic routes.

Application

• Homogeneous Catalysis: As a key ligand in palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings.
• Pharmaceutical Intermediates: For the synthesis of complex, high-value drug candidates and active pharmaceutical ingredients (APIs) requiring high selectivity.
• Agrochemical Synthesis: In the development of novel herbicides, fungicides, and insecticides where efficient C-C and C-N bond formation is crucial.
• Materials Science: For catalyzing polymerization reactions and the synthesis of organic electronic materials, such as OLEDs and semiconductors.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and process chemistry laboratories.
• Fine Chemical Production: Enabling efficient, scalable synthesis of specialty chemicals and complex organic molecules.

Basic Information

Product Name	2-(2'-Di-tert-Butylphosphine)Biphenyl
CAS No.	577971-19-8
Molecular Formula	C20H27P
Molecular Weight	298.40 g/mol
Synonyms	2-(Di-tert-butylphosphino)biphenyl; 2-Biphenyldi-tert-butylphosphine; Di-tert-butyl(2-biphenylyl)phosphine; DTBPB; JohnPhos-type ligand; tBuBPhos; 2-(Di-tert-butylphosphanyl)biphenyl; (2-Biphenylyl)di-tert-butylphosphine
EINECS	Contact for details

Quality Control

Our production of 2-(2'-Di-tert-Butylphosphine)Biphenyl adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for catalytic applications. Each lot is characterized by NMR (1H, 13C, 31P) and HPLC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Handle and open containers only in a controlled, oxygen-free environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR Purity	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.