Description

6α-Hydroxy Budesonide is a key pharmaceutical intermediate and metabolite of the anti-inflammatory corticosteroid budesonide. This compound is of significant importance for research and development in the synthesis of advanced steroid-based therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on respiratory and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of budesonide and related corticosteroid APIs.
• Metabolite Reference Standard: Used in pharmacokinetic and drug metabolism studies to understand the behavior of budesonide in biological systems.
• Analytical Research: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Process Development: Employed in the optimization and scaling of manufacturing processes for steroid drugs.
• Biochemical Research: Used in studies investigating the mechanism of action and metabolic pathways of glucocorticoids.

Basic Information

Product Name	6α-Hydroxy Budesonide
CAS No.	577777-51-6
Molecular Formula	C25H34O7
Molecular Weight	446.53 g/mol
Synonyms	6α-Hydroxybudesonide; 6α-Hydroxy-16α,17α-butylidenedioxy-11β,21-dihydroxypregna-1,4-diene-3,20-dione; Budesonide 6α-Hydroxy Derivative; 6α-Hydroxy-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde; 6α-Hydroxy Budesonide Impurity
EINECS	Contact for details

Quality Control

Our 6α-Hydroxy Budesonide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.