Description

1-n-Cbz-Nipecotamide is a high-purity, protected nipecotic acid derivative, serving as a critical chiral building block in advanced organic synthesis. This compound is essential for medicinal chemists developing novel pharmaceutical candidates, particularly those targeting the central nervous system. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and sophisticated chemical intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for neurological disorders.
• Peptide Mimetics Synthesis: Used to incorporate constrained amino acid analogs into peptide chains to enhance stability and biological activity.
• Ligand and Receptor Probe Development: Serves as a precursor for creating specialized molecules used in biochemical and pharmacological studies.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new catalytic systems.
• Chemical Library Construction: A valuable building block for generating diverse compound libraries in high-throughput screening for drug discovery.
• Academic and Industrial R&D: Fundamental research tool in synthetic organic chemistry for methodology development and complex molecule construction.

Basic Information

Product Name	1-n-Cbz-Nipecotamide
CAS No.	569348-14-7
Molecular Formula	C14H18N2O3
Molecular Weight	262.31 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-piperidinecarboxamide; N-Cbz-Nipecotamide; 1-Carbobenzoxy-3-piperidinecarboxamide; 1-(Benzyloxycarbonyl)piperidine-3-carboxamide; 3-(Carbamoyl)-1-piperidinecarboxylic acid benzyl ester; Nipecotamide, N-Cbz-; Benzyl 3-carbamoylpiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-Nipecotamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.