Description

(E)-3-(4-Bromo-2-Fluorophenyl)Acrylamide is a high-purity, halogenated acrylamide derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular structure, which enables the introduction of both bromo and fluoro substituents onto a conjugated acrylamide scaffold, facilitating the development of novel chemical entities. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including potential active pharmaceutical ingredients (APIs) and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, leveraging the bioactivity of the fluorinated phenyl ring.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with specific optical or electronic properties.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis and molecular recognition studies.
• Chemical Biology Probes: Utilized as a building block for creating fluorescent tags or activity-based probes for biochemical research.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-fidelity halogenated intermediates.

Basic Information

Product Name	(E)-3-(4-Bromo-2-Fluorophenyl)Acrylamide
CAS No.	568595-13-1
Molecular Formula	C9H7BrFNO
Molecular Weight	244.06 g/mol
Synonyms	(E)-3-(4-Bromo-2-fluorophenyl)prop-2-enamide; trans-3-(4-Bromo-2-fluorophenyl)acrylamide; 4-Bromo-2-fluorocinnamamide; (E)-3-(4-Bromo-2-fluorophenyl)-2-propenamide; 2-Fluoro-4-bromocinnamamide; (E)-3-(4-Bromo-2-fluorophenyl)acrylic acid amide; NSC 781836; AKOS005258155
EINECS	Contact for details

Quality Control

Every batch of (E)-3-(4-Bromo-2-Fluorophenyl)Acrylamide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications tailored to meet the stringent requirements of process chemistry and scale-up. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.