Description

Amyloid Beta/A4 Protein Precursor770 (586-595) (Human, Mouse, Rat) CAS NO 566173-30-6 is a synthetic peptide fragment corresponding to a specific sequence of the amyloid precursor protein (APP). This high-purity research-grade peptide is critical for studying the molecular mechanisms underlying Alzheimer's disease and related neurodegenerative disorders. It is an essential tool for neuroscientists, pharmaceutical researchers, and diagnostic developers focused on β-amyloid aggregation, toxicity, and biomarker discovery.

Application

• Neuroscience Research: Fundamental studies on the processing, aggregation kinetics, and neurotoxic effects of amyloid-beta peptides.
• Drug Discovery & Screening: Used as a standard or target in high-throughput assays to identify and validate potential therapeutic compounds that inhibit amyloid aggregation or promote clearance.
• Antibody Development & Validation: Serves as a critical antigen for the production, characterization, and specificity testing of monoclonal and polyclonal antibodies used in research and diagnostics.
• Diagnostic Assay Development: Employed as a calibrator or control in the development of immunoassays (ELISA, Western Blot) for detecting amyloid-beta species in biological samples.
• Biomarker Studies: Utilized in proteomics and biomarker research to understand the role of specific APP fragments in disease progression.
• Academic & Institutional Research: Supports basic and translational research in university and hospital laboratories worldwide.

Basic Information

Product Name	Amyloid Beta/A4 Protein Precursor770 (586-595) (Human, Mouse, Rat)
CAS No.	566173-30-6
Molecular Formula	C55H84N14O13
Molecular Weight	1125.3 g/mol
Synonyms	APP(586-595); Amyloid Beta A4 Protein (586-595); Aβ Precursor Protein 770 fragment (586-595); KMDAEFRHDS; APP770 (586-595); Amyloid Precursor Protein Peptide (586-595); Human/Mouse/Rat APP Peptide
EINECS	Contact for details

Quality Control

This peptide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot is characterized by analytical HPLC for purity and mass spectrometry (MS) for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and analytical data, supporting research that demands reliable and reproducible biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (HPLC)	≥95%
Peptide Content	≥70%
Molecular Weight	1125.3 ± 1.0 Da
Identification (Mass Spec)	Consistent with theoretical mass
Solubility	Soluble in water or dilute aqueous acetic acid
Single-Letter Sequence	KMDAEFRHDS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.