Description

Boc-Dl-Cyclobutylalanine is a protected amino acid derivative of significant value in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediates: Key chiral synthon in the research and development of new drug candidates, particularly for metabolic and central nervous system (CNS) targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the cyclobutylalanine moiety, which can influence peptide conformation and biological activity.
• Proteomics Research: Employed in the synthesis of custom peptides for biochemical assays, enzyme substrate studies, and protein-protein interaction analysis.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by allowing the exploration of sterically constrained, non-natural amino acid analogs.
• Bioconjugation: Acts as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Chemical Biology Tool Development: Integral for synthesizing peptide-based probes, inhibitors, and fluorescent tags used in cellular imaging and mechanistic studies.

Basic Information

Product Name	Boc-Dl-Cyclobutylalanine
CAS No.	565456-75-9
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-DL-cyclobutylalanine; Boc-Cbu-OH; (RS)-2-((tert-Butoxycarbonyl)amino)-2-cyclobutylacetic acid; DL-2-((tert-Butoxycarbonyl)amino)-2-cyclobutylacetic acid; tert-Butyl (RS)-1-(carboxymethyl)cyclobutylcarbamate; N-Boc-DL-2-amino-2-cyclobutylacetic acid; Cyclobutylalanine, N-Boc-DL-; Boc-DL-2-Cyclobutylglycine
EINECS	Contact for details

Quality Control

Our Boc-Dl-Cyclobutylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.