Description

4,4'-Di-n-Acetylamino-Diphenylsulfone-D8 is a deuterated analog of the pharmaceutical intermediate 4,4'-Diacetyldiaminodiphenyl sulfone (DADDS), where eight hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for enhancing the precision and reliability of analytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug development, analytical method validation, and the synthesis of isotopically labeled reference standards.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, stable isotope-labeled internal standard for the quantitative bioanalysis of DADDS and related sulfone compounds in complex biological matrices.
• Metabolic Pathway Tracing: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and elucidate metabolic pathways and degradation products.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for the calibration of analytical instruments and validation of assay methods in quality control laboratories.
• Deuterated Building Block: Acts as a specialized synthon in the research-scale synthesis of more complex deuterated molecules for various investigative purposes.
• Stability and Mechanism Studies: Facilitates research into chemical stability, reaction mechanisms, and environmental fate studies where isotopic labeling is required.

Basic Information

Product Name	4,4'-Di-n-Acetylamino-Diphenylsulfone-D8
CAS No.	557794-37-3
Molecular Formula	C16H8D8N2O4S
Molecular Weight	332.40 g/mol
Synonyms	DADDS-D8; 4,4'-Diacetyldiaminodiphenyl sulfone-D8; 4,4'-Sulfonylbis(acetanilide)-D8; N,N'-(Sulfonylbis(4,1-phenylene))diacetamide-D8; Bis(4-acetamidophenyl) sulfone-D8; Acedapsone-D8; DADDS (phenyl-D8); 1,1'-Sulfonylbis(4-acetamidobenzene)-D8
EINECS	Contact for details

Quality Control

Our 4,4'-Di-n-Acetylamino-Diphenylsulfone-D8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for isotopic purity verification and HPLC for chemical purity assessment, to ensure it meets the exacting standards required for research and analytical applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which could affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.