Description

Fmoc-15-Amino-4,7,10,13-Tetraoxapentadecanoic Acid is a specialized, high-purity building block designed for advanced peptide synthesis and bioconjugation. Its core value lies in the unique hydrophilic tetraoxapentadecanoic acid spacer, which enhances the solubility and pharmacokinetic properties of the final constructs. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-drug conjugates (PDCs), antibody-drug conjugates (ADCs), and other sophisticated biomolecules where controlled spacing and improved aqueous compatibility are critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the controlled incorporation of a long, flexible, and hydrophilic polyethylene glycol (PEG)-like linker into peptide chains.
• Peptide-Drug Conjugate (PDC) Development: Serves as a key spacer/linker to connect cytotoxic drugs to targeting peptides, improving solubility and reducing aggregation.
• Antibody-Drug Conjugate (ADC) Linker Technology: Used in the synthesis of advanced, cleavable or non-cleavable linker systems to optimize the stability and efficacy of ADCs.
• Bioconjugation and Protein Labeling: Facilitates the site-specific attachment of probes, dyes, or other molecules to proteins and antibodies via its carboxylic acid and amine functionalities.
• Synthesis of PEGylated Biomolecules: Acts as a discrete, monodisperse PEG mimic to modify peptides and proteins, enhancing their circulatory half-life and stability.
• Drug Delivery System Research: Employed in creating novel nanocarriers and delivery platforms that require hydrophilic spacers for optimal biodistribution.

Basic Information

Product Name	Fmoc-15-Amino-4,7,10,13-Tetraoxapentadecanoic Acid
CAS No.	557756-85-1
Molecular Formula	C29H37NO9
Molecular Weight	543.61 g/mol
Synonyms	Fmoc-NH-PEG4-CH2CH2COOH; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-15-amino-4,7,10,13-tetraoxapentadecanoic acid; Fmoc-PEG4-acid; Fmoc-Amino-PEG4-Acid; 15-[(9-Fluorenylmethyloxycarbonyl)amino]-4,7,10,13-tetraoxapentadecanoic acid; Fmoc-N-amido-PEG4-acid; Fmoc-NH-(PEG)4-COOH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request. We adhere to strict quality management protocols suitable for cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.