Description

Cefuroxime Free Acid CAS NO 555268-75-2 is the active pharmaceutical ingredient (API) form of the second-generation cephalosporin antibiotic, cefuroxime. This compound serves as the critical intermediate for the synthesis of various cefuroxime salts, such as cefuroxime sodium and cefuroxime axetil, which are used in final dosage formulations. It is essential for pharmaceutical manufacturers and research institutions engaged in developing injectable and oral antibiotic products targeting a broad spectrum of bacterial infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary raw material for the industrial-scale production of cefuroxime sodium for sterile injectable solutions.
• Prodrug Manufacturing: Key starting material in the synthesis of cefuroxime axetil, the prodrug used in oral tablet and suspension formulations.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies for developing new antibiotic formulations and combination therapies.
• Generic Drug Production: Sourced by generic pharmaceutical companies for manufacturing bioequivalent versions of branded cefuroxime products.
• Veterinary Medicine: Employed in the development of antibacterial treatments for veterinary use.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in laboratories.

Basic Information

Product Name	Cefuroxime Free Acid
CAS No.	555268-75-2
Molecular Formula	C16H16N4O8S
Molecular Weight	424.39 g/mol
Synonyms	(6R,7R)-3-[(Carbamoyloxy)methyl]-7-[[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefuroxime Acid; Cefuroxime; (Z)-Cefuroxime; Cefuroxime Free Acid (Z-Isomer); Cefuroxime (Base); Antibiotic GR 20263
EINECS	Contact for details

Quality Control

Our Cefuroxime Free Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide Certificates of Analysis (COA) detailing specifications for identity, purity, and impurities, referencing relevant pharmacopeial guidelines. GMP-compliant documentation and full traceability are maintained for all production lots.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.