Description

2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-([1,1'-Biphenyl]-4-Yl)Propanoic Acid is a sophisticated, non-natural amino acid derivative featuring a biphenyl side chain and an Fmoc-protected α-amino group. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of aromatic, hydrophobic character and structural rigidity into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key reagent for the automated, stepwise construction of custom peptide sequences, particularly those requiring enhanced aromatic interactions.
• Peptidomimetic Drug Discovery: Serves as a crucial scaffold for creating peptide analogs with improved metabolic stability, bioavailability, and target binding affinity by incorporating a rigid biphenyl moiety.
• Chemical Biology Research: Used in the synthesis of peptide probes, inhibitors, and labeled compounds for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Material Science & Specialty Polymers: Can be incorporated into novel polymeric materials where precise sequence control and aromatic functionality are desired for specific mechanical or electronic properties.
• Pharmaceutical Intermediate: Acts as a high-purity intermediate in the synthesis of active pharmaceutical ingredients (APIs) for candidates targeting GPCRs, kinases, and other protein targets.

Basic Information

Product Name	2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-([1,1'-Biphenyl]-4-Yl)Propanoic Acid
CAS No.	553643-52-0
Molecular Formula	C30H25NO4
Molecular Weight	463.53 g/mol
Synonyms	Fmoc-4-Biphenylalanine; Fmoc-Bip(4)-OH; Fmoc-4-Bpa-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-biphenylalanine; 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-biphenylyl)propanoic acid; N-α-Fmoc-4-biphenylalanine; Fmoc-DL-4-Biphenylalanine; N-Fmoc-4-biphenylalanine
EINECS	Contact for details

Quality Control

Our 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-([1,1'-Biphenyl]-4-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep the container tightly sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.