Description

(R)-1-Boc-3-Acetamidopyrrolidine CAS NO 550371-67-0 is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold for constructing complex molecules with precise three-dimensional architecture. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Peptidomimetics Research: Used to construct proline-like scaffolds and conformationally constrained peptide analogs in drug discovery.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Intermediate in the production of chiral herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Building block for creating labeled compounds and molecular probes to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	(R)-1-Boc-3-Acetamidopyrrolidine
CAS No.	550371-67-0
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	(R)-3-Acetamido-1-(tert-butoxycarbonyl)pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-3-acetamidopyrrolidine; (R)-N-{1-[(tert-Butoxy)carbonyl]pyrrolidin-3-yl}acetamide; (R)-1-Boc-3-acetamidopyrrolidine; tert-Butyl (3R)-3-(acetylamino)pyrrolidine-1-carboxylate; (R)-3-Acetylamino-1-Boc-pyrrolidine; (R)-1-Boc-3-(acetylamino)pyrrolidine; Boc-(R)-3-AcNH-Pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Acetamidopyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.