Description

2H-Cyclohepta[4,5]Furo[2,3-D]Pyrimidine-2,4(3H)-Dione, 1,5-Dihydro-5-(Methoxy-D3)-1,3-Dimethyl- (9Ci) is a deuterated heterocyclic compound of significant interest in advanced pharmaceutical research and development. This high-value specialty chemical serves as a critical building block for creating isotopically labeled drug candidates and metabolites. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, metabolic studies, and analytical method development. The incorporation of deuterium (D3) offers unique advantages for pharmacokinetic and pharmacodynamic investigations.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel, deuterium-labeled active pharmaceutical ingredients (APIs) for improved metabolic stability.
• Metabolic Research: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate quantification of drugs and metabolites in biological matrices.
• Drug Discovery & Development: Employed in medicinal chemistry programs to explore structure-activity relationships (SAR) and optimize the pharmacokinetic profiles of lead compounds.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for method validation and quality control in analytical laboratories.
• Isotope Labeling Studies: Facilitates mechanistic studies in chemistry and biology by tracing reaction pathways and metabolic fate.

Basic Information

Product Name	2H-Cyclohepta[4,5]Furo[2,3-D]Pyrimidine-2,4(3H)-Dione, 1,5-Dihydro-5-(Methoxy-D3)-1,3-Dimethyl- (9Ci)
CAS No.	548475-69-0
Molecular Formula	C₁₃H₁₂D₃NO₄
Molecular Weight	Contact for details
Synonyms	5-(Methoxy-d3)-1,3-dimethyl-1,5-dihydro-2H-cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione; 1,5-Dihydro-5-(methoxy-d3)-1,3-dimethyl-2H-cyclohepta[4,5]furo[2,3-d]pyrimidine-2,4(3H)-dione; Deuterated Methoxy Cycloheptafuropyrimidinedione; CAS 548475-69-0
EINECS	Contact for details

Quality Control

Our 2H-Cyclohepta[4,5]Furo[2,3-D]Pyrimidine-2,4(3H)-Dione, 1,5-Dihydro-5-(Methoxy-D3)-1,3-Dimethyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.