Description

Benzeneacetonitrile, -α--Hydroxy-2,4,6-Trimethyl-, (-α-R)- (9Ci) is a chiral, optically active organic compound featuring a benzonitrile core with a hydroxy-substituted α-carbon. This specific stereochemistry and functional group arrangement make it a valuable chiral building block and intermediate in advanced synthetic chemistry. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for the synthesis of complex, stereochemically defined molecules. The compound's structure is ideal for constructing active pharmaceutical ingredients (APIs) and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in enantioselective synthesis.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where biological activity is dependent on molecular chirality.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fragrance compounds, flavors, and other specialty chemicals requiring precise stereocontrol.
• Academic and Industrial R&D: A critical reagent for methodological development in organic chemistry and for exploring new synthetic pathways in process chemistry.

Basic Information

Product Name	Benzeneacetonitrile, -α--Hydroxy-2,4,6-Trimethyl-, (-α-R)- (9Ci)
CAS No.	545386-91-2
Molecular Formula	C11H13NO
Molecular Weight	175.23 g/mol
Synonyms	(R)-2-Hydroxy-2-(2,4,6-trimethylphenyl)acetonitrile; (αR)-α-Hydroxy-2,4,6-trimethylbenzenecetonitrile; (R)-2,4,6-Trimethylmandelonitrile; (R)-α-Hydroxy-2,4,6-trimethylbenzeneacetonitrile; (R)-TMN; (R)-2-(2,4,6-Trimethylphenyl)-2-hydroxyacetonitrile; (R)-2-Hydroxy-2-mesitylacetonitrile; (R)-Mandelonitrile, 2,4,6-trimethyl-
EINECS	Contact for details

Quality Control

Every batch of Benzeneacetonitrile, -α--Hydroxy-2,4,6-Trimethyl-, (-α-R)- (9Ci) is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with industry standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.