Description

Celecoxib-D7 is a stable isotope-labeled analog of the nonsteroidal anti-inflammatory drug (NSAID) Celecoxib, where seven hydrogen atoms are replaced by deuterium. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily used by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of Celecoxib in complex biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the metabolic pathways, bioavailability, and pharmacokinetic profile of Celecoxib in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Enables the development, optimization, and validation of robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical Trial Support: Facilitates accurate therapeutic drug monitoring and pharmacokinetic analysis during clinical trials involving Celecoxib.
• Pharmaceutical Quality Control: Acts as a reference material for impurity profiling and assay verification of Celecoxib in active pharmaceutical ingredient (API) and finished dosage form analysis.
• Forensic and Toxicology Analysis: Supports the accurate identification and quantification of Celecoxib in forensic and toxicological investigations.

Basic Information

Product Name	Celecoxib-D7
CAS No.	544686-21-7
Molecular Formula	C17H7D7F3N2O2S
Molecular Weight	388.40 g/mol
Synonyms	4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-D7; Celecoxib (phenyl-D5, methyl-D2); Celecoxib-d7; Deuterated Celecoxib; Celebrex-D7; SC-58635-D7; [D7]-Celecoxib
EINECS	Contact for details

Quality Control

Our Celecoxib-D7 is manufactured under strict quality systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive mass spectrometry applications. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and results from identity confirmation tests. We support compliance with cGMP and relevant ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.