Description

Celecoxib-D4 is a deuterated analog of the selective cyclooxygenase-2 (COX-2) inhibitor Celecoxib, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors, particularly for pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of Celecoxib in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Metabolite Identification: Used in mass spectrometry to distinguish drug-derived metabolites from endogenous compounds, facilitating metabolic pathway elucidation.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and regulatory-compliant (FDA, EMA) analytical methods for Celecoxib.
• Quality Control in Pharmaceutical Manufacturing: Ensures batch-to-batch consistency and purity assessment of active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Doping Control Analysis: Supports the accurate detection and quantification of Celecoxib in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Celecoxib-D4
CAS No.	544686-20-6
Molecular Formula	C17D4F3N3O2S
Molecular Weight	385.39 g/mol
Synonyms	4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-D4; Celecoxib (phenyl-D4); Celecoxib-d4; SC-58635-d4; YM-177-d4; 4-[5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide-d4
EINECS	Contact for details

Quality Control

Our Celecoxib-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic purity assessment, and HPLC for chemical purity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic enrichment, and residual solvents. Our quality commitment ensures the material meets the stringent requirements for use in GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.