Description

Celecoxib-D3 (Methyl-D3) is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) Celecoxib, specifically labeled with three deuterium atoms on the methyl group. This stable isotope-labeled compound is an essential internal standard for the accurate quantification of Celecoxib in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development to ensure data integrity and regulatory compliance.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in the quantitative analysis of Celecoxib in plasma, serum, and other biological samples via mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, and Excretion) studies to track and quantify the parent drug and its metabolites.
• Clinical Research: Enables precise measurement of drug concentrations in clinical trials for Celecoxib, supporting bioavailability and bioequivalence studies.
• Forensic and Toxicology Testing: Facilitates accurate detection and quantification of Celecoxib in forensic analyses and toxicological screenings.
• Pharmaceutical Quality Control: Can be utilized in method development and validation for the assay of Celecoxib in pharmaceutical dosage forms.
• Isotope Dilution Mass Spectrometry (IDMS): Employed as a spike in IDMS protocols to achieve high-precision and accurate results, minimizing matrix effects.

Basic Information

Product Name	Celecoxib-D3 (Methyl-D3)
CAS No.	544686-18-2
Molecular Formula	C17H11D3F3N2O2S
Molecular Weight	384.39 g/mol
Synonyms	4-[5-(4-Methyl-d3-phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; Celecoxib Methyl-d3; Celecoxib (methyl-d3); Celecoxib-d3; Deuterated Celecoxib; [2H3]-Celecoxib; SC-58635-d3
EINECS	Contact for details

Quality Control

Our Celecoxib-D3 (Methyl-D3) is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is characterized by NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.