Description

2-(tert-Butoxycarbonylamino)-4,4,4-Trifluorobutanoic Acid is a high-value, protected amino acid derivative featuring a trifluoromethyl group. This compound is a critical chiral building block in organic synthesis, prized for its role in introducing fluorine atoms and the versatile Boc-protected amine functionality into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptides, peptidomimetics, and potential drug candidates targeting metabolic and central nervous system disorders.
• Agrochemical Research: Used in creating novel fluorinated pesticides and herbicides, where the trifluoromethyl group can enhance biological activity, metabolic stability, and lipophilicity.
• Fluorine Chemistry & Material Science: Serves as a precursor for specialty chemicals, liquid crystals, and polymers where fluorine incorporation modifies physical properties like chemical resistance and thermal stability.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative to construct complex fluorinated peptide sequences.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and inhibitors for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-(tert-Butoxycarbonylamino)-4,4,4-Trifluorobutanoic Acid
CAS No.	544479-61-0
Molecular Formula	C9H14F3NO4
Molecular Weight	257.21 g/mol
Synonyms	Boc-4,4,4-trifluoro-DL-norvaline; 2-[(tert-Butoxycarbonyl)amino]-4,4,4-trifluorobutanoic acid; 4,4,4-Trifluoro-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; N-Boc-4,4,4-trifluoronorvaline; N-(tert-Butoxycarbonyl)-4,4,4-trifluoronorvaline; 4,4,4-Trifluoro-N-[(2-methyl-2-propanyl)oxycarbonyl]norvaline; (RS)-2-(tert-Butoxycarbonylamino)-4,4,4-trifluorobutanoic acid
EINECS	Contact for details

Quality Control

Our production of 2-(tert-Butoxycarbonylamino)-4,4,4-Trifluorobutanoic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure consistency and compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.