Description

(S,S)-F-Binaphane is a specialized chiral ligand belonging to the binaphthyl phosphine family, distinguished by its fluorine substitution. This compound matters for its critical role in facilitating highly enantioselective transition metal-catalyzed reactions, enabling the production of single-isomer intermediates essential for advanced pharmaceuticals and agrochemicals. Industries requiring asymmetric synthesis, particularly in pharmaceutical R&D and fine chemical manufacturing, need this high-performance ligand to achieve superior stereochemical control and process efficiency.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediates.
• Catalyst component for enantioselective C-C bond-forming reactions (e.g., cross-coupling).
• Key reagent in the synthesis of optically active natural products and agrochemicals.
• Use in academic and industrial research for developing new catalytic methodologies.
• Production of chiral active pharmaceutical ingredients (APIs) under GMP conditions.
• Asymmetric synthesis of flavors, fragrances, and other specialty fine chemicals.

Basic Information

Product Name	(S,S)-F-Binaphane
CAS No.	544461-38-3
Molecular Formula	C44H32F2P2
Molecular Weight	672.67 g/mol
Synonyms	(S,S)-1,1'-Bis[(R)-1-(diphenylphosphino)ethyl]-2,2'-bis(trifluoromethanesulfonyloxy)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; (S,S)-2,2'-Bis(α-(diphenylphosphino)ethyl)-1,1'-binaphthyl; (S,S)-F-BINAPHANE; F-Binaphane ligand; (S,S)-H8-BINAP derivative
EINECS	Contact for details

Quality Control

Our (S,S)-F-Binaphane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding catalytic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.