Description

Siltuximab is a chimeric monoclonal antibody specifically designed to target and neutralize human interleukin-6 (IL-6). This product is critical for research and development in the biopharmaceutical sector, particularly in the study of cytokine signaling pathways and associated diseases. It is essential for scientists and manufacturers developing targeted therapies for conditions driven by IL-6, such as certain cancers and autoimmune disorders. Siltuximab CAS NO 541502-14-1 represents a high-purity biological reagent for advanced therapeutic and diagnostic applications.

Application

• Biopharmaceutical R&D: Primary reagent for investigating the role of IL-6 in disease pathology and validating therapeutic targets.
• Therapeutic Antibody Development: Used as a reference standard or starting material in the development of biosimilar or next-generation anti-IL-6 biologics.
• Preclinical Studies: Essential for in vitro and in vivo models to assess the efficacy of IL-6 blockade in oncology and immunology research.
• Diagnostic Assay Development: Serves as a key component in the development of immunoassays (e.g., ELISA) to detect and quantify IL-6 or anti-IL-6 antibodies.
• Cell Culture & Protein Interaction Studies: Used to inhibit IL-6 in cell-based assays to study its effects on proliferation, differentiation, and inflammatory responses.
• Process Development & Quality Control: Employed in downstream purification process development and as a system suitability standard in analytical methods for related products.

Basic Information

Product Name	Siltuximab
CAS No.	541502-14-1
Molecular Formula	Contact for details
Molecular Weight	~144 kDa
Synonyms	Anti-IL-6 Monoclonal Antibody; cCLB8; CNTO 328; IL-6 Antibody; Immunoglobulin G1, anti-(human interleukin 6) (human-mouse monoclonal cCLB8 γ1-chain), disulfide with human-mouse monoclonal cCLB8 κ-chain, dimer; Sylvant (Trade Name)
EINECS	Contact for details

Quality Control

Our Siltuximab is manufactured and tested under stringent quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is characterized for purity, identity, potency, and endotoxin levels using advanced analytical techniques including HPLC, SDS-PAGE, and cell-based bioassays. Certificates of Analysis (COA) detailing all release specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE, HPLC-SEC)	> 95%
Protein Content (UV Absorbance)	As per COA
Biological Activity (Cell-based Assay)	> 90% of reference standard
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.