Description

1-Pyrrolidineacetonitrile,3-Hydroxy-,(3S)-(9Ci) is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific stereochemistry and functional groups into their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in neurological and metabolic disorder research.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective reactions to create enantiomerically pure compounds.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical Production: Employed in the multi-step synthesis of complex specialty chemicals, flavors, and fragrances.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory chemistry in university and CRO laboratories.
• Peptidomimetics: Useful in the design and synthesis of peptide analogs and protease inhibitors due to its pyrrolidine backbone.

Basic Information

Product Name	1-Pyrrolidineacetonitrile,3-Hydroxy-,(3S)-(9Ci)
CAS No.	540787-77-7
Molecular Formula	C7H12N2O
Molecular Weight	140.18 g/mol
Synonyms	(3S)-3-Hydroxypyrrolidine-1-acetonitrile; (S)-3-Hydroxypyrrolidine-1-acetonitrile; 1-Acetonitrile, 3-hydroxy-, (3S)-pyrrolidine; 3-Hydroxy-1-pyrrolidineacetonitrile, (S)-; (S)-(-)-3-Hydroxypyrrolidine-1-acetonitrile; 1-Cyanomethyl-3(S)-hydroxypyrrolidine; (3S)-3-Hydroxy-1-pyrrolidineacetonitrile
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidineacetonitrile,3-Hydroxy-,(3S)-(9Ci) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.