Description

4’-Hydroxy Atomoxetine -D-Glucuronide is a key glucuronide metabolite of the selective norepinephrine reuptake inhibitor atomoxetine. This compound matters significantly for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of bioanalytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced drug metabolism and pharmacokinetic (DMPK) studies, metabolite identification, and regulatory bioanalysis.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of atomoxetine metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in in vitro and in vivo studies to understand the metabolic pathways, clearance mechanisms, and exposure levels of atomoxetine and its derivatives.
• Bioanalytical Method Development: Essential for developing and validating sensitive and specific LC-MS/MS or HPLC-UV methods for therapeutic drug monitoring and clinical studies.
• Metabolite Profiling & Identification: Aids in the structural confirmation and characterization of human metabolites as part of regulatory safety and efficacy packages (e.g., for FDA, EMA submissions).
• Toxicology Studies: Employed to investigate the potential role of specific metabolites in the overall safety profile of the parent drug.
• Impurity Standard: Can be used as a known impurity or degradation product standard for the quality control of atomoxetine active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	4’-Hydroxy Atomoxetine -D-Glucuronide
CAS No.	540729-08-6
Molecular Formula	C25H30ClNO8
Molecular Weight	508.0 g/mol (approx.)
Synonyms	4'-Hydroxyatomoxetine D-Glucuronide; Atomoxetine 4'-O-β-D-Glucuronide; (3R)-N-Methyl-3-(4'-hydroxyphenoxy)-3-phenylpropylamine D-Glucuronide; LY-139603 Glucuronide; Tomoxetine Metabolite Glucuronide; (R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine 4'-Glucuronide; 4'-OH-Atomoxetine Glucuronide
EINECS	Contact for details

Quality Control

Our 4’-Hydroxy Atomoxetine -D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.