Description

(S)-Tetrahydrofuran-2-Carbonitrile is a high-value, chiral nitrile derivative of tetrahydrofuran, serving as a critical chiral building block in advanced organic synthesis. Its enantiopure structure is essential for introducing stereochemical complexity into target molecules with high precision. This compound is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Building Block: Employed in academic and industrial R&D for constructing complex heterocyclic compounds and natural product analogs.
• Material Science Research: Potential monomer or precursor for specialized polymers with unique optical or mechanical properties.

Basic Information

Product Name	(S)-Tetrahydrofuran-2-Carbonitrile
CAS No.	539820-24-1
Molecular Formula	C5H7NO
Molecular Weight	97.12 g/mol
Synonyms	(S)-2-Cyanotetrahydrofuran; (S)-Tetrahydro-2-furancarbonitrile; (2S)-Oxolane-2-carbonitrile; (S)-THF-2-CN; (S)-2-Tetrahydrofurancarbonitrile; (S)-Tetrahydrofuran-2-carbonitrile; (S)-2-Cyanooxolane
EINECS	Contact for details

Quality Control

Our (S)-Tetrahydrofuran-2-Carbonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and GC-MS. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.