Description

4-Fluoro-3-(trifluoromethyl)phenacyl bromide is a versatile and highly functionalized organic bromide intermediate. This compound is valued for its unique trifluoromethyl and fluoro substituents, which impart desirable properties such as enhanced lipophilicity and metabolic stability to target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for use in synthesis, particularly in the construction of complex fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where fluorination improves bioactivity and environmental persistence.
• Material Science Research: Serves as a precursor for fluorinated monomers or ligands used in specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the creation of tagged molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed reactions (e.g., Suzuki, Heck) to introduce fluorinated aromatic groups.
• Academic & Contract Research: Essential reagent for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)phenacyl bromide
CAS No.	537050-14-9
Molecular Formula	C9H5BrF4O
Molecular Weight	285.04 g/mol
Synonyms	2-Bromo-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone; 4-Fluoro-3-(trifluoromethyl)phenacyl bromide; 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-2-bromoethanone; α-Bromo-4'-fluoro-3'-(trifluoromethyl)acetophenone; 2-Bromo-4'-fluoro-3'-(trifluoromethyl)acetophenone; 4-Fluoro-α-bromo-3-(trifluoromethyl)acetophenone; 537050-14-9
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)phenacyl bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive and should be handled accordingly.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.