Description

2-Fluoro-4-(trifluoromethyl)phenacyl bromide is a versatile and highly functionalized organic building block, specifically a phenacyl bromide derivative. This compound is valued for its reactive bromomethyl ketone group and the electron-withdrawing trifluoromethyl and fluorine substituents, which make it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved activity and environmental profile.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and advanced organic materials with specific electronic or optical properties.
• Chemical Biology & Proteomics: Can be utilized as an affinity label or a reactive handle for modifying proteins and other biomolecules in research applications.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Heterocyclic Chemistry: A valuable starting material for the construction of various nitrogen- and oxygen-containing heterocycles, which are common scaffolds in medicinal chemistry.

Basic Information

Product Name	2-Fluoro-4-(trifluoromethyl)phenacyl bromide
CAS No.	537050-12-7
Molecular Formula	C9H5BrF4O
Molecular Weight	285.04 g/mol
Synonyms	2-Bromo-1-[2-fluoro-4-(trifluoromethyl)phenyl]ethanone; 1-(2-Fluoro-4-(trifluoromethyl)phenyl)-2-bromoethanone; α-Bromo-2-fluoro-4-(trifluoromethyl)acetophenone; 2-Fluoro-α-bromo-4-(trifluoromethyl)acetophenone; 2'-Fluoro-4'-(trifluoromethyl)phenacyl bromide; 2-Bromo-2'-fluoro-4'-(trifluoromethyl)acetophenone
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-(trifluoromethyl)phenacyl bromide is manufactured and tested under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.