Description

2-Fluoro-3-(trifluoromethyl)phenacyl bromide is a high-value, multi-functional fluorinated aromatic building block. This compound is critical for introducing the phenacyl bromide moiety into target molecules, enabling further synthetic elaboration. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of fluorinated aromatic systems.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialty polymers with enhanced chemical resistance and thermal stability.
• Ligand Synthesis: Building block for creating complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: A versatile substrate for further functionalization via nucleophilic substitution or metal-catalyzed cross-coupling reactions.
• Chemical Biology: Used to create probes and tags for studying biological processes due to its reactive bromide handle.

Basic Information

Product Name	2-Fluoro-3-(Trifluoromethyl)Phenacyl Bromide
CAS No.	537050-11-6
Molecular Formula	C9H5BrF4O
Molecular Weight	285.04 g/mol
Synonyms	2-Bromo-1-[2-fluoro-3-(trifluoromethyl)phenyl]ethan-1-one; 2'-Fluoro-3'-(trifluoromethyl)phenacyl Bromide; α-Bromo-2-fluoro-3-(trifluoromethyl)acetophenone; 1-(2-Fluoro-3-(trifluoromethyl)phenyl)-2-bromoethanone; 2-Bromo-2'-fluoro-3'-(trifluoromethyl)acetophenone; Bromo(2-fluoro-3-(trifluoromethyl)phenyl)methanone
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)phenacyl bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for your synthetic workflows. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.