Description

4-Bromo-2,3,6-Trifluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and fluorine substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic features into complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and longevity.
• Advanced Polymer Chemistry: Employed to incorporate fluorinated phenylacetic acid moieties into specialty polymers, enhancing material properties like chemical resistance and thermal stability.
• Chemical Research & Development: A versatile reagent for exploring new coupling reactions and constructing complex fluorinated aromatic scaffolds in academic and industrial R&D settings.

Basic Information

Product Name	4-Bromo-2,3,6-Trifluorophenylacetic Acid
CAS No.	537033-59-3
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	2-(4-Bromo-2,3,6-trifluorophenyl)acetic Acid; (4-Bromo-2,3,6-trifluorophenyl)acetic Acid; 4-Bromo-2,3,6-trifluorobenzeneacetic Acid; α-(4-Bromo-2,3,6-trifluorophenyl)acetic Acid; 537033-59-3; 4-Bromo-2,3,6-trifluorophenylacetic acid; Acetic acid, 2-(4-bromo-2,3,6-trifluorophenyl)-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3,6-Trifluorophenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	<10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.