Description

4-Chloro-2,6-Difluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of chlorine and fluorine atoms is crucial for modulating biological activity and metabolic stability. It is needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Serves as a key building block for developing advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety enhances lipophilicity and systemic activity.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated aromatic cores for electronic and photonic materials, contributing to improved stability and performance.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Chemical Research & Development: A versatile reagent for exploring new carbon-carbon and carbon-heteroatom bond-forming reactions in academic and industrial laboratories.

Basic Information

Product Name	4-Chloro-2,6-Difluorophenylacetic Acid
CAS No.	537033-55-9
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	2-(4-Chloro-2,6-difluorophenyl)acetic Acid; (4-Chloro-2,6-difluorophenyl)acetic Acid; 4-Chloro-2,6-difluorobenzeneacetic Acid; α-(4-Chloro-2,6-difluorophenyl)acetic Acid; 537033-55-9; 4-Chloro-2,6-difluoro-phenyl-acetic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,6-Difluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. Certificates of Analysis (COA) with complete batch data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.