Description

n-(1-Oxohexadecyl)-L-Glutamic Acid tert-Butyl Ester is a high-purity, synthetic amino acid derivative designed for advanced chemical synthesis. This compound serves as a crucial protected intermediate, offering selective reactivity for the construction of complex peptides and lipidated molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and specialty chemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel peptide-based therapeutics and drug candidates.
• Lipopeptide Synthesis: Used to introduce lipophilic (palmitoyl) chains onto peptide backbones, enhancing membrane permeability and stability.
• Bioconjugation: Facilitates the site-specific modification of proteins, antibodies, or other biomolecules for drug delivery and diagnostic applications.
• Chemical Biology Research: Employed in the study of protein-lipid interactions and the development of chemical probes.
• Cosmetic Peptide Production: Acts as an intermediate for synthesizing anti-aging and skin-repairing bioactive peptides.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing client-specific compounds.

Basic Information

Product Name	n-(1-Oxohexadecyl)-L-Glutamic Acid tert-Butyl Ester
CAS No.	536721-25-2
Molecular Formula	C25H47NO5
Molecular Weight	441.65 g/mol
Synonyms	N-Palmitoyl-L-glutamic acid 1-tert-butyl ester; N-Hexadecanoyl-L-glutamic acid 5-tert-butyl ester; L-Glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester; Palmitoyl-Glu(OtBu)-OH; Boc-Glu(Palmitoyl)-OtBu (common abbreviation); N-(1-Oxohexadecyl)glutamic Acid tert-Butyl Ester; Glutamic acid derivative CAS 536721-25-2
EINECS	Contact for details

Quality Control

Our n-(1-Oxohexadecyl)-L-Glutamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural verification. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.