Description

2-Chloro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing the pyridine and trifluoromethyl pharmacophores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific halogenated pyridine structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for creating biaryl and heterobiaryl compounds under mild conditions.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid exploration of structure-activity relationships (SAR) in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	536693-96-6
Molecular Formula	C6H4BClF3NO2
Molecular Weight	225.36 g/mol
Synonyms	[2-Chloro-5-(trifluoromethyl)pyridin-3-yl]boronic acid; 2-Chloro-5-(trifluoromethyl)-3-pyridineboronic acid; 3-Borono-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-5-trifluoromethylpyridine-3-boronic acid; (2-Chloro-5-(trifluoromethyl)pyridin-3-yl)boronic acid; 2-Chloro-5-(trifluoromethyl)-3-pyridinylboronic acid; 536693-96-6; BCPB
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.