Description

Benzamide, n-[(1R,2R,6R)-2-Hydroxy-5-Oxo-7-Oxabicyclo[4.1.0]Hept-3-En-3-Yl]- is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and bicyclic oxabicyclo[4.1.0]heptene core structure. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in modern medicinal chemistry. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop new therapeutic agents, especially in areas requiring chiral specificity and complex molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to create new drug candidates.
• Asymmetric Synthesis: Serves as a precursor or scaffold in catalytic asymmetric reactions due to its defined stereocenters.
• Protease Inhibitor Development: Potential building block for compounds targeting enzymatic pathways, given the benzamide moiety.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	Benzamide, n-[(1R,2R,6R)-2-Hydroxy-5-Oxo-7-Oxabicyclo[4.1.0]Hept-3-En-3-Yl]-
CAS No.	534583-65-8
Molecular Formula	C14H13NO4
Molecular Weight	259.26 g/mol
Synonyms	N-[(1R,2R,6R)-2-Hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide; (1R,2R,6R)-3-Benzamido-2-hydroxy-7-oxabicyclo[4.1.0]hept-3-ene-5-one; 7-Oxabicyclo[4.1.0]hept-3-ene-3-carboxamide, N-phenyl-, (1R,2R,6R)-2-hydroxy-5-oxo-; Benzamide derivative of 2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-ene
EINECS	Contact for details

Quality Control

Our Benzamide, n-[(1R,2R,6R)-2-Hydroxy-5-Oxo-7-Oxabicyclo[4.1.0]Hept-3-En-3-Yl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is likely light-sensitive and may be hygroscopic; therefore, storage under an inert atmosphere in a desiccated environment is recommended for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.