Description

Ephrin-A2-Selective Ysa-Peptide is a synthetic, biologically active peptide designed for high-affinity and selective binding to the Ephrin type-A receptor 2 (EphA2). This specificity makes it a critical research tool for studying receptor-ligand interactions, downstream signaling pathways, and cellular processes like angiogenesis and tumorigenesis. It is primarily utilized by researchers and developers in the fields of oncology, neurobiology, and drug discovery for target validation, assay development, and as a reference standard.

Application

• Biomedical Research: Used as a selective agonist/antagonist to investigate EphA2 receptor function and signaling cascades in cancer and neurological studies.
• Drug Discovery & Development: Serves as a key reference compound and competitive inhibitor in high-throughput screening (HTS) assays for novel EphA2-targeted therapeutics.
• Cell Biology Studies: Applied in vitro to modulate cell adhesion, migration, and proliferation in assays exploring tumor metastasis and angiogenesis.
• Diagnostic Assay Development: Employed in the development and calibration of ELISA, SPR (Surface Plasmon Resonance), or other binding assays to detect EphA2 activity.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes studying tyrosine kinase receptor biology and intercellular communication.
• Biopharmaceutical QC: Potential use as a purity and activity reference standard in the quality control of biopharmaceutical products targeting the Ephrin pathway.

Basic Information

Product Name	Ephrin-A2-Selective Ysa-Peptide
CAS No.	532441-10-4
Molecular Formula	C41H62N12O12S
Molecular Weight	923.06 g/mol
Synonyms	YSA Peptide; YSAYPDSVPMMS; Ephrin A2-binding peptide; EphA2-binding YSA peptide; TNYL-RAW competitor peptide; Eph receptor-interacting peptide; 4-({2-[({2-[({2-[(2-{2-[({2-[(2-amino-2-oxoethyl)amino]-2-oxoethyl}amino)-2-oxoethyl]amino}-2-oxoethyl)amino]-2-oxoethyl}amino)methyl]-1H-imidazol-1-yl}methyl)-1H-imidazol-1-yl]acetic acid; Contact for IUPAC name.
EINECS	Contact for details

Quality Control

Our Ephrin-A2-Selective Ysa-Peptide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or aqueous buffer
Single-Letter Sequence	YSAYPDSVPMMS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.