Description

2-(Trifluoromethoxy)Phenacyl Bromide is a specialized organobromine building block characterized by its phenacyl bromide core functionalized with a trifluoromethoxy substituent. This compound is valued for its dual reactivity, serving as both an alkylating agent and a precursor for further functionalization, particularly in the synthesis of complex heterocycles and fluorinated fine chemicals. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group can improve biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for catalysis and molecular recognition studies.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or affinity probes due to the reactive bromoacetyl group.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Product Name	2-(Trifluoromethoxy)Phenacyl Bromide
CAS No.	530141-40-3
Molecular Formula	C9H6BrF3O2
Molecular Weight	283.04 g/mol
Synonyms	2-Bromo-1-[2-(trifluoromethoxy)phenyl]ethanone; 1-(2-(Trifluoromethoxy)phenyl)-2-bromoethanone; α-Bromo-2'-(trifluoromethoxy)acetophenone; 2-(Trifluoromethoxy)phenacyl bromide; 2-Bromo-2'-(trifluoromethoxy)acetophenone; 1-(2-(Trifluoromethoxyphenyl))-2-bromoethanone
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Phenacyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive and should be handled under inert atmosphere for prolonged storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.