Description

(-)-1,2-Bis((2R,5R)-2,5-Diphenylphospholano)Ethane is a high-value, chiral bisphosphine ligand essential for creating highly selective asymmetric catalytic systems. Its precise stereochemistry enables the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs) with exceptional efficiency. This ligand is a critical component for R&D and manufacturing in the global pharmaceutical, agrochemical, and fine chemical industries, where reaction selectivity and yield are paramount.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective hydrogenation of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Pharmaceutical Intermediate Production: Key for manufacturing chiral building blocks and complex molecules for APIs, including those for cardiovascular and central nervous system drugs.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Fine Chemical Catalysis: Enables high-value transformations in specialty chemical production, such as the synthesis of flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A vital tool for chemists developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Transition Metal Complex Formation: Serves as a chelating agent to form robust rhodium, ruthenium, and iridium complexes for homogeneous catalysis.

Basic Information

Product Name	(-)-1,2-Bis((2R,5R)-2,5-Diphenylphospholano)Ethane
CAS No.	528565-79-9
Molecular Formula	C34H34P2
Molecular Weight	504.58 g/mol
Synonyms	(R,R)-(-)-1,2-Bis(2,5-diphenylphospholano)ethane; (R,R)-DIPAMP-Analogue Bisphospholane Ligand; (-)-1,2-Bis[(2R,5R)-2,5-diphenylphospholano]ethane; (R,R)-Et-BisPHOS; (2R,2'R,5R,5'R)-1,1'-(Ethane-1,2-diyl)bis(2,5-diphenylphospholane); DuPhos-type Ligand; Chiral Diphospholane Ligand
EINECS	Contact for details

Quality Control

Every batch of (-)-1,2-Bis((2R,5R)-2,5-Diphenylphospholano)Ethane is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity. Our products undergo rigorous analytical testing, including chiral HPLC, NMR, and elemental analysis, to guarantee compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Elemental Analysis	Conforms to theoretical values

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.