Description

(S)-(-)-7,7'-Bis[Di(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is a high-value, chiral phosphine ligand essential for creating highly selective asymmetric catalytic systems. Its unique spirobiindane backbone and sterically demanding substituents provide exceptional enantioselectivity and stability in transition metal complexes. This ligand is a critical component for researchers and process chemists in the pharmaceutical and fine chemical industries developing novel synthetic routes to chiral intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing single-enantiomer pharmaceutical building blocks.
• Asymmetric C-C Bond Formation: Enables highly selective cross-coupling, allylic alkylation, and conjugate addition reactions for constructing complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Used in the development and commercial-scale production of chiral drugs, including those for cardiovascular, central nervous system, and metabolic diseases.
• Agrochemical Synthesis: Applied in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Catalyst Screening & Development: A key tool in academic and industrial R&D for discovering new asymmetric transformations and optimizing catalytic processes.
• Material Science Research: Investigated for the synthesis of chiral polymers and advanced materials with unique optical properties.

Basic Information

Product Name	(S)-(-)-7,7'-Bis[Di(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane
CAS No.	528521-89-3
Molecular Formula	C53H52P2
Molecular Weight	751.92 g/mol
Synonyms	(S)-SIPHOS-PE; (S)-(-)-SIPHOS; (S)-DTBM-SEGPHOS; (S)-7,7'-Bis(di-3,5-xylylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (S)-(-)-DTBM-SEGPHOS; (S)-3,5-DTBM-SEGPHOS; (S)-Bis(3,5-dimethylphenyl)(2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diyl)bisphosphane; (S)-(-)-7,7'-Bis(di-3,5-xylylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobiindane
EINECS	Contact for details

Quality Control

Our (S)-(-)-7,7'-Bis[Di(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized; containers should be flushed with inert gas after each opening to minimize degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.