Description

(R)-(+)-7,7'-Bis[Di(4-Methylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its unique spirobiindane backbone provides exceptional steric and electronic control, enabling highly enantioselective transformations critical for producing optically pure intermediates. This ligand is indispensable for R&D and production chemists in the pharmaceutical and fine chemical industries seeking to develop novel chiral APIs and advanced materials with superior selectivity and yield.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Chiral API Intermediate Production: Critical for constructing stereogenic centers in complex drug molecules, including antibiotics, antivirals, and cardiovascular agents.
• Cross-Coupling Reactions: Employed in asymmetric cross-coupling processes to form carbon-carbon and carbon-heteroatom bonds with high enantiomeric excess.
• Fine Chemical Synthesis: Used in the manufacture of specialty chemicals, agrochemicals, and flavors & fragrances requiring precise chirality.
• Catalyst Screening & Development: A key component in catalyst libraries for high-throughput screening and the development of new catalytic systems in academic and industrial R&D.
• Material Science Research: Facilitates the synthesis of chiral polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(R)-(+)-7,7'-Bis[Di(4-Methylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane
CAS No.	528521-87-1
Molecular Formula	C54H48P2
Molecular Weight	758.90 g/mol
Synonyms	(R)-SpiroBIAP; (R)-7,7'-Bis(di-p-tolylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (R)-DTB-SpiroBIAP; (R)-SpiroBIP; (R)-(+)-SpiroBIAP; (R)-2,2',3,3'-Tetrahydro-7,7'-bis(di-4-methylphenylphosphino)-1,1'-spirobiindane; Ligand (R)-L5; (R)-L5
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-7,7'-Bis[Di(4-Methylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is manufactured and tested under strict quality management systems. We guarantee high chemical and optical purity to meet the rigorous demands of asymmetric synthesis. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and chiral integrity are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The material is easily oxidized; avoid exposure to air during handling and use.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.