Description

(R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its unique spirobiindane backbone provides exceptional steric and electronic properties, enabling highly enantioselective transformations critical for producing optically pure intermediates. This ligand is indispensable for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control in hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic synthesis of chiral active pharmaceutical ingredients (APIs) and key building blocks.
• Agrochemical Manufacturing: Enables the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Facilitates asymmetric C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations.
• Academic & Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Fine Chemical Production: Applied in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane
CAS No.	528521-86-0
Molecular Formula	C41H34P2
Molecular Weight	588.65 g/mol
Synonyms	(R)-(+)-SDP; (R)-SDP; (R)-7,7'-Bis(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (R)-2,2',3,3'-Tetrahydro-7,7'-bis(diphenylphosphino)-1,1'-spirobiindane; (R)-Spirobiindanebis(diphenylphosphine); (R)-Spiro-SDP; (R)-SpiroBIP; (R)-H8-BINAP (structural analog)
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane is manufactured and tested under strict quality management systems. We guarantee high chemical and chiral purity to ensure optimal catalytic performance and reproducibility in your processes. Comprehensive analytical data, including HPLC purity, chiral HPLC for enantiomeric excess (ee), and 31P NMR verification, is provided with each Certificate of Analysis (COA). Our quality commitment aligns with cGMP principles for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
31P NMR	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.