Description

1-Bromo-3-(1,1,2,2-Tetrafluoroethoxy)Benzene is a high-value fluorinated aromatic building block, distinguished by its unique combination of a bromine substituent and a tetrafluoroethoxy side chain. This structure makes it a critical intermediate for introducing both fluorine content and a reactive halogen site into advanced molecular architectures. It is primarily sought after by R&D and process chemists in the pharmaceutical and agrochemical sectors for applications requiring precise fluorination and subsequent cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Polymer & Specialty Chemicals: Incorporated into high-performance polymers and specialty surfactants to impart oil- and water-repellent (fluorinated) properties.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) for creating complex, functionalized aromatic systems.
• Research & Development: A versatile reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Bromo-3-(1,1,2,2-Tetrafluoroethoxy)Benzene
CAS No.	527751-45-7
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	3-Bromo-1-(1,1,2,2-tetrafluoroethoxy)benzene; m-Bromo(1,1,2,2-tetrafluoroethoxy)benzene; 1-Bromo-3-(perfluoroethoxy)benzene; Benzene, 1-bromo-3-(1,1,2,2-tetrafluoroethoxy)-; 3-(1,1,2,2-Tetrafluoroethoxy)phenyl bromide; 3-Bromo-α,α,β,β-tetrafluoroanisole
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(1,1,2,2-Tetrafluoroethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.