Description

2-Amino-3,3-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block for the synthesis of novel, biologically active molecules, particularly protease inhibitors and other therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the creation of next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially protease inhibitors.
• Peptidomimetics: Used to incorporate difluorinated phenylalanine analogs into peptide backbones to enhance metabolic stability and binding affinity.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting various disease pathways.
• Bioconjugation: Potential use in the synthesis of labeled compounds or antibody-drug conjugates (ADCs) due to its reactive amino and carboxylic acid functional groups.
• Chemical Biology: Employed as a tool compound or probe to study enzyme mechanisms and protein interactions.
• Fine Chemical Synthesis: A specialized building block for the custom synthesis of complex, fluorinated organic molecules in contract research and manufacturing.

Basic Information

Product Name	2-Amino-3,3-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride
CAS No.	527751-26-4
Molecular Formula	C9H9F3NO2 • HCl
Molecular Weight	267.63 g/mol (Free base: 231.17)
Synonyms	(2R/S)-2-Amino-3,3-difluoro-3-(4-fluorophenyl)propanoic acid hydrochloride; DL-2-Amino-3,3-difluoro-3-(4-fluorophenyl)propionic acid HCl; 3-(4-Fluorophenyl)-3,3-difluoroalanine hydrochloride; 2-Amino-3,3-difluoro-3-(4-fluorophenyl)propanoic acid hydrochloride; 4-Fluoro-α,α-difluoro-β-alanine, 3-amino- hydrochloride (racemic); 527751-26-4; Amino-difluoro(fluorophenyl)propionic acid HCl
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3,3-difluoro-3-(4-fluorophenyl)propionic acid hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, chiral purity (if applicable), and impurity profiles are available for each lot. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.