Description

Methyl (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-Iodopropanoate is a high-purity, non-natural amino acid derivative designed for advanced chemical synthesis. This compound is a critical building block for the controlled introduction of iodine and protected amino acid functionality into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected iodinated amino acid ester for the controlled assembly of custom peptide sequences.
• Medicinal Chemistry & Drug Discovery: A versatile intermediate for constructing molecular libraries and exploring structure-activity relationships (SAR) in lead optimization.
• Bioconjugation: Serves as a precursor for site-specific labeling of proteins, antibodies, or other biomolecules via iodine-mediated coupling reactions.
• Chemical Biology Probes: Used in the synthesis of activity-based probes or affinity tags for studying enzyme function and protein interactions.
• Organocatalyst & Ligand Development: Acts as a chiral scaffold for the synthesis of novel catalysts and ligands used in asymmetric synthesis.
• Material Science: A building block for synthesizing functionalized polymers or dendrimers with specific chemical handles.

Basic Information

Product Name	Methyl (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-Iodopropanoate
CAS No.	527696-77-1
Molecular Formula	C19H18INO4
Molecular Weight	451.16 g/mol
Synonyms	Fmoc-3-iodo-L-alanine methyl ester; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-iodopropanoic acid methyl ester; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-alaninate; Fmoc-I-Ala-OMe; Fmoc-3-Iodoalanine methyl ester; N-α-Fmoc-3-iodo-L-alanine methyl ester; L-Alanine, 3-iodo-, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, providing full traceability and batch-specific information.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.