Description

Huwentoxin Iv CAS NO 526224-73-7 is a highly selective and potent peptide neurotoxin derived from the venom of the Chinese bird spider, *Haplopelma huwenum*. This compound is a critical research tool for studying voltage-gated sodium channels (NaV), particularly the NaV1.7 subtype, due to its specific inhibitory action. It is essential for pharmaceutical and academic researchers focused on pain pathway research, neurological disorder studies, and novel analgesic drug discovery. Its high purity and biological activity make it indispensable for advanced electrophysiology and in vitro pharmacological assays.

Application

• Neuroscience Research: A primary tool for blocking tetrodotoxin-sensitive (TTX-S) sodium channels, specifically NaV1.7, in neuronal cell studies.
• Pain Research & Drug Discovery: Used in target validation and screening assays for the development of new non-opioid analgesic compounds.
• Electrophysiology: Employed in patch-clamp experiments to characterize sodium channel function and pharmacology in various cell types.
• Ion Channel Pharmacology: Serves as a reference standard for studying channel kinetics, subtype specificity, and toxin-receptor interactions.
• Biochemical Studies: Used in binding assays and structural biology to understand toxin-channel interactions at the molecular level.
• Academic & Pharmaceutical R&D: Critical for basic research in university labs and for target identification in biotech and pharmaceutical companies.

Basic Information

Product Name	Huwentoxin Iv
CAS No.	526224-73-7
Molecular Formula	C185H274N52O55S7
Molecular Weight	4210.9 g/mol
Synonyms	Huwentoxin-IV; HwTx-IV; μ-Theraphotoxin-Hh2a; NaV1.7 Blocker; Voltage-gated sodium channel inhibitor; Spider toxin peptide; Haplopelma huwenum toxin IV; Neurotoxic peptide; Analgesic peptide candidate
EINECS	Contact for details

Quality Control

Our Huwentoxin Iv is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to GMP principles for research-grade biomolecules, ensuring traceability, consistency, and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be aliquoted to avoid repeated freeze-thaw cycles. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Biological Activity (IC50)	Reported value provided per batch
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.