Description

Dextrorphan-D3 -D-o-Glucuronide is a high-purity, stable isotope-labeled metabolite of dextrorphan, a key compound in pharmacological research. This deuterated glucuronide conjugate is essential for precise quantitative analysis in drug metabolism and pharmacokinetic (DMPK) studies, serving as a critical internal standard. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of dextrorphan and related metabolites in biological matrices.
• Drug Metabolism Studies: Used to investigate Phase II conjugation pathways, specifically glucuronidation, to understand the metabolic fate and clearance of dextromethorphan and its active metabolite, dextrorphan.
• Pharmacokinetic (PK) & Bioanalytical Assay Development: Critical for developing and validating robust, sensitive, and specific analytical methods to support preclinical and clinical trials.
• Forensic & Clinical Toxicology: Employed in confirmatory testing and method development for detecting and quantifying drug exposure in forensic and clinical settings.
• Biomarker Research: Facilitates research into metabolic biomarkers associated with drug efficacy, safety, and individual metabolic phenotypes.

Basic Information

Product Name	Dextrorphan-D3 -D-o-Glucuronide
CAS No.	524713-58-4
Molecular Formula	C23H28D3NO8
Molecular Weight	~ 446.5 g/mol
Synonyms	Dextrorphan D3 Glucuronide; (+)-3-Hydroxy-N-methylmorphinan-D3 glucuronide; Dextrorphan-d3 β-D-Glucopyranosiduronic Acid; Dextrorphan (D3) Glucuronide; Dextrorphan Glucuronide-d3; Dextrorphan-D3 Glucuronide Conjugate; 17-Methyl-9α,13α,14α-morphinan-3-ol-D3 glucuronide
EINECS	Contact for details

Quality Control

Our Dextrorphan-D3 -D-o-Glucuronide is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS analysis. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium, D)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.