Description

Dextromethorphan-D3 is a deuterium-labeled isotopologue of the common antitussive agent, Dextromethorphan. This stable isotope-labeled compound is essential for use as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical research and development, clinical laboratories, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalysis.
• Pharmacokinetic Research: Enables precise measurement of Dextromethorphan absorption, distribution, metabolism, and excretion in clinical and preclinical studies.
• Drug Metabolism Studies: Used to investigate metabolic pathways and identify metabolites without interference from endogenous compounds.
• Forensic and Clinical Toxicology: Supports accurate quantification of Dextromethorphan in biological samples for diagnostic and legal purposes.
• Pharmaceutical Quality Control: Applicable in the development and validation of analytical methods for drug substance and product testing.
• Reference Material Manufacturing: Serves as a key component in the production of certified reference materials (CRMs) and quality control kits.

Basic Information

Product Name	Dextromethorphan-D3
CAS No.	524713-56-2
Molecular Formula	C18H22D3NO
Molecular Weight	274.41 g/mol
Synonyms	(+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan-D3; Dextromethorphan (phenyl-d3); Dextromethorphan-d3; DXM-d3; 1,2,3,4,5,6,7,8-Octahydro-17-methyl-3-methoxy-4,5α-epoxy-17-azamethanobenzocyclododecen-11-ol-d3; Ro 1-5470-d3; d-Methorphan-d3
EINECS	Contact for details

Quality Control

Our Dextromethorphan-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing purity (assay), isotopic enrichment, and solvent content, supporting compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.